Antibacterial drug aminoglycosides

Nafcillin Sodium Nafcillin sodium is not compatible with other antibacterials, including aminoglycosides, acidic drugs, and alkaline drugs. 

Antibacterial drugs that affect bacterial protein synthesis include the aminoglycosides, tetracyclines, macrolides, and the single drug chloramphenicol. 

Antibacterial drugs that inhibit protein synthesis aminoglycosides, tetracyclines, macrolldes and chloramphenicol... 

Antibacterial drugs Some intravitreal antibacterial drugs, such as aminoglycosides, are toxic to the retina, even at low doses. Vancomycin is non-toxic at the recommended dose, but the concentrations achieved in a silicon-filled eye were unpredictable. 

It is extremely important that fluoroquinolones have a specific mechanism of action, different from antibiotics and other groups of antibacterials (cephalosporins, aminoglycosides, etc.), which allows one to apply fluoroquinolones for treatment of infectious diseases caused by strains resistant to many other classes of antibacterials drugs. 

The discovery of a novel structural class of antibacterials is notable, as these are few and far between. The sulfa drugs, p-lactams, quinohnes, tetracyclines, macrohdes, and aminoglycosides have been around for decades. Multiple improvements have been made over time in each of these classes but without breaking out into new structural classes. There are two notable, recent examples of new stractural classes of antibacterials and these are worth knowing about. 

The quinolone antibiotics feature as the one main gronp of antibacterial agents that is totally synthetic, and not derived from or based upon natural products, as are penicillins, cephalosporins, macrolides, tetracyclines, and aminoglycosides. The first of these compounds to be employed clinically was nalidixic acid more recent drugs in current use include ciprofloxacin, norfloxacin, and ofloxacin... 

The arsenal of antibacterials available for the treatment of infectious diseases has expanded exponentially since then. Currently, as illustrated in Fig. 1, the repertoire includes the (J-lactams (e.g. 3) sulfa drugs (e.g. 4) macrolides (e.g. 5, erythromycin A), nitrofuran drugs (e.g. 6, furazolidone), and many aminoglycosides. 

Clinical Use. Paromomycin (Humatin) is an aminoglycoside antibacterial (see Chapter 33) that is used primarily to treat mild to moderate intestinal infections (amebiasis).51 This drug may also be used as an adjunct to other amebicides during the treatment of more severe protozoal infections. Paromomycin is also effective against some bacteria and tapeworms, and may be used as a secondary agent in certain bacterial or helminthic infections. This drug is administered orally. 

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