Antibacterial activity bacterial strains

Some representative examples of the new compounds were tested against a pathogenic bacterial strain and have shown activity against Staphylococcus aureus ATCC 25923. The benzodiazepin-2-one 69 offers the strongest antibacterial activity. The results are summarized in Table 8. 

Since the introduction of nalidixic acid in 1963, structural modifications on the quinolones have been performed to improve either the antibacterial efficacy or pharmacokinetic/toxicologic profiles of these compounds. The newest quinolones possess broad-spectrum activity, favorable pharmacokinetic/toxicologic profiles, and potency against bacterial strains that are resistant to older generations of quinolones. This section describes the synthetic procedures for the new generation of quinolones that were studied during the 1995-2005 period. 

The oh.scT ation that certain catechol-substituted cephalo-.sporins exhibit marked broad-spectrum antibacterial activity l to the discovery that such compounds and other analogues capable of chelating iron could mimic natural sidero-phores (iron-chelating peptides) and thus be actively transported into bacterial cells via the roiiB-dependent iron-transport sy.stem." This provides a meaas of attacking bacterial strains that resist cellular penetration of eephalo-.sporins. 

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