1.4- diamino butane

Figure 14.1 Energy minimized CPK models of generation 0 through 4 PAMAM and PPI dendrimers. EDA ethylene diamine DAB diamino butane G generation number numbers of end groups given in parentheses...

Ein Syntheseweg zu cw-1,2-Diamino-cyclobutanen geht von der photosensibilisierten Cycloaddition von Alkenen an 1,3-Diacetyl-2-oxo-2,3-dihydro-imidazole aus die entste-henden 2,4-Diaeetyl-3-oxo-2,4-diaza-bicyclo[3.2.0]heptane werden isoliert und alkalisch zu cis-1,2-Diamino-butan hydrolysiert1. Man erhalt so z. B. aus Ethen in zwei Stufen mit je 77% und 63% Ausbeute cis-1,2-Diamino-cyclobutan, aus Propen cis-1,2-Di-amino-3-methyl-cyclobutan (l.Stufe 75% 2.Stufe 62%) und aus 2-Methyl-propen cis-l,2-Diamino-3,3-dimethvl-cvcbbutan (l.Stufe 66Vo 2.Stufe 50%) ... 

A major impact in the treatment of HIV involves anti-retroviral therapy with APIs that belong to a class known as the avir family of highly active pharmaceuticals. A number of these avirs contain the l-phenyl-2,4-diamino-butan-3-ol fragment (Q). 

NOTE Higher nitrated derivs of Diamino-butane were not found in Beil or in CA thru 1961... 

An interesting phenomenon was recently discovered when (Ph2Si0)8[A10 (OH)]4-2 H2N(CH2)4NH2 is reacted with a further equivalent of 1,4-diamino-butane. A two-dimensional polymer is obtained of the composition (Ph2Si0)8[A10 (OH)]4-3 H2N(CH2)4NH2, the structure of which is sketched in Fig. 18. The structure can be derived from that of (Ph2SiO)8[A10(OH)]4 2 H2N(CH2)4NH2 by... 

For example, one type of dendrimer is made by reacting 1,4-diamino-butane with four molecules of acrylonitrile (CH2 = CHGN), as shown... 

Fig. 1.5. Dependence of the electroenz3maatic response (Ay) of lactate dehydrogenase modified gold electrodes on the time of protein layer growth (a) mixed 3-mercaptopropamol and 3-mercaptopropionic acid SAM derivatized with 1,4-diamino-butane ligand fi-ee- ( ), CB- (O) and Ll-anchored (A) (b) cystamine SAM derivatized with fumaric acid ligand fi-ee- ( ), CB- (O) and Ll-anchored (A). The monolayers were incubated in a 0.36mgml enzyme solution in 50 mM Na-phosphate buffer, pH 7.0. Reproduced from [240] with permission.

Polyfpropylene imine) dendrimers are prepared by a divergent route, using 1,4-diamino butane as the core molecule and acrylonitrile (CH2=CHCN) as the monomer branch unit. Growth occurs via the two-stage process (a) a double Michael addition of acrylonitrile to the core followed by (b) hydrogenation under pressure to the nitrile group to a primary amine. 

In this class of dendrimers, ethylenediamine or diamino-butane is nsed as the core, while acrylonitrile molecules are used as the branching units. The chemical architecture of PPl dendrimers closely resembles PAMAM dendrimers. However, the internal architecture in PPl... 

THE CRYSTAL STRUCTURES OF a, co-DIAMINOALKANECADMIUM(II) TETRACYANO-NICKELATE(II)-AROMATIC MOLECULE INCLUSION COMPOUNDS. I. 1,4-DIAMINO-BUTANE CADMIUM( I I) TETRACYANONICKELATE(II)-2,5-XYLIDINE (1/1) ... 

Chelate Complexes. In the analysis of c/s-dichIoro-(>wcso-2,3-diamino-butane)palladium(ii) (46) all the hydrogen atoms were located staggered conformations are found at the exocyclic C-C bonds, and the chelate... 

Caymans et al. [16] prepared poly(tetramethylene-l,6-hexanediamide)-6-polyoxytetramethylene by polycondensation of a,a -diamino-polyoxytetrameth-ylene with the salt of hexanedioic acid and 1,4-diamino-butane (Scheme 15). 

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