Anti-plaque additives

HHV-6 and HHV-7 from the Rh olovirus genus present a high distribution worldwide with infection rates of respectively 70-100% and 75% (7,8]. Primary infection with HHV-6 results in the development of exanthema subitum and can lead to complications such as malaise, febrile seizures and in some rare cases encephalitis [7]. HHV-6 is heavily associated with diseases of the central nervous system in immunocompromised patients such as encephalitis and/or encephalopathy 7], but also with multiple sclerosis. In particular, anti-HHV-6 antibodies and HHV-6 DNA have been detected in MS cerebrospinal fluid and MS plaques, respectively [9]. So far, the link of HHV-7 and diseases other than exanthema subitum during primary infection remains highly speculative 9-11]. Additional studies are required to understand the true contribution of HHV-7 in pathological conditions. 

The first inflammatory stage of atherosclerosis starts early in life with more severe lesions developing only if classical risk factors, especially cholesterol, remain present. Immune responses mounted against antigens cross-react with homologous host proteins in a form of molecular mimicry, for example, HSP are secreted by C. pneumoniae, H. pylori, mammalian vascular cells exposed to stress such as CVD risk factors, and cells within atherosclerotic plaques In addition, serum titers of anti-HSP antibodies are correlated positively with the future risk of CHD, and purified anti-HSP antibodies lyse stressed human EC and macrophages in vitro. Furthermore, immunization with HSP exacerbate athersclerosis in animal models (reviewed in refs. 212,213). However, there is molecular mimicry between epitopes of oxLDL and Streptococcus pneumonia in LDLR -/- mice pneumococcal immunization led to increased IgM levels against oxLDL and decreased the extent of atherosclerosis (214). 

The objective of the current study was to compare the anti-psoriatic effect of six topical producfs using a modified version of the original psoriasis plaque test with emphasis on the predictive capacity of fhis model. Validation of the use of immunohistochemical and histological scoring of biopsy materials, in conjxmction with chemical scoring, in the prediction of anti-psoriatic effecfs was an additional objective [S ]. 

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