Anti-MRSA activity

Table 15 Anti-MRSA Activity of Pterocarpans from the Genus Erythrina...

Hardej et al. [22] have synthesized a series of rhodanine derivatives containing various substituents at the N3- and Cg-positions and tested for in vitro antibacterial activity against a panel of clinically relevant methicillin-resistant Staphylococcus aureus (MRSA) strains. The anti-MRSA activity of compounds II (minimum inhibitory concentration (MIC)=3.9 pg/mL) and in (MIC=1.95 pg/mL) were significantly greater than that of the reference antibiotics penicillin G (MIC=31.25 pg/mL) and ciprofloxacin (MIC=7.8 pg/mL). 

We also screened anti-MRSA flavonoids [115] in the course of the study of anti-Helicobacter pylori flavonoids from licorice described in Chapter X. In our screening (Table 6), glabrene (24), licoisoflavone B (67), and gancaonin I (126) also exhibited anti-MRSA effect. Among these compounds, 23, 24, 27, 59, 61, 62, 63, 67, and 126 exhibited relatively high anti-bacterial activities against B. subtilis (HI7), Table 7. 

Eriotrichin B 70 (also called Bidwillon A) was found 10 be antibacterial against S aureus with MIC50 of 8.3 pg/ml [20], while 2,3-dihydropratcnscin (5 7,3 -trihydroxy-4 -methoxyisoflavanone) 71 showed antifungal activity against Cladosporium cucumerinum (2 pg) in a TLC bioautography preliminary assay [12]. Orientanol F 72 showed Anti-MRSA... 

Activated sulfonamides and other activated amines were used in a series of Mitsunobu reactions to prepare analogs of 2-(sulfanamido)methyl carbapenems (124) as potential anti-MRSA compounds. The basic reaction scheme and some of the activated amines that were used are shown in the figure below. Additional examples can be found in the original paper. 

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