Anti-inflammatory enantiomerically pure 5 -2-arylpropionic

Arylpropionic acids are important class of non-steroidal anti-inflammatory drugs (NSAID). Their pharmacological activity is mainly in one of both enantiomers. Thus, efforts had been made to access to the enantiomerically pure substance. The kinetic resolution of racemic 2-(2-fluoro-4-biphenyl) propanoic acid 56 and 2(4-isobutylphenyl) propanoic acid 59 (Ibuprofen) was performed via enzymatic esterification and transesterification using an alcohol and vinyl acetate, respectively in a membrane reactor. The unreacted acid is obtained in highly enantiomerically enriched form. A consecutive approach consisting of the enzymatic hydrolysis of the resulted esters is needed to achieve the alcohol in optically pure form.77... 

Ibuprofen and naproxen as 2-arylpropionic acids belong to an important new class of nonsteroidal anti-inflammatory agents42. Asymmetric hydrocarboxylation of styrenes thus represents a direct access to optically active or enantiomerically pure probes. 

The asymmetric aUcoxycarbonylation of aUcenes is a reaction of particular interest, especially for vinylarenes, because it gives a two steps access (alkoxycarbonyla-tion, ester hydrolysis) to enantiomerically pure carboxylic acids from alkenes. For instance, a few arylpropionic acids such as (S j-Ibuprofen, (5)-Ketoprofen, and (5)-Naproxen, are popular non-steroidal anti-inflammatory agents [99]. Although good regio- and enantioselectivities have already been reported for asymmetric aUcoxycarbonylation, no systems, to the best of our knowledge, possesses both types of selectivities [100-104]. We tested ligands 7 in the asymmetric... 

Chemoenzymatic Preparation of Enantiomerically Pure S(+)-2-Arylpropionic Acids with Anti-Inflammatory Activity... 

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