Anti-inflammatory effect neuropathy

Evening Primrose Oil (Oenof/iera biennis) Uses PMS, diabetic neuropathy, ADHD, IBS, RA, mastalgia Action Anti-inflammatory, antispas-modic, diuretic, sedative effects related to a high concentration of essential fatty acids esp GLA CLA their conversion into prostaglandins Available forms Caps, gel-caps, Liq dose depends on GLA content DM neuropathy 4000-6000 mg PO OD Eczema 4000 mg PO OD Mastalgia 3000 1000 mg PO -r doses PMS 2000-4000 mg PO OD RA Up to 5000 mg PO OD Notes/SE Indigestion, N, soft stools, flatulence, HA, anorexia, rash Contra Do not use PRG or lactation do not use persons w/ Sz disorders Interactions T Phenobarbital metabolism, i Sz threshold, T effects OF diuretics, sedatives EMS May take up to 4 mo for max effectiveness T risk of Szs... 

Potential therapeutic benefits of antioxidants to reduce intracellular oxidative stress have not yet been evaluated in vasculific neuropathy associated w ith autoimmune disease. Such anti-oxidants as vitamin E, a-lipoic acid or benfotiamine may be effective in interrupting the pro-inflammatory transcription factors and subsequent NF-[kappa]B regulated cytokines that initiate and maintain inflammation associated w ith vasculific neuropathy (Haselbeck et al., 2004). 

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