Anti-inflammatory compounds oxicams

Another compound structurally related to the oxicams is RU 43526 (159) [387], which gave approximately equipotent inhibition of seminal vesicle CO (2.1 //M) and of rat ISN (3.0 //M). Removal of the 2-substituent had no effect on the CO inhibition, but drastically reduced 5-LO potency. RU 43526 was orally active, but only in NSAID-sensitive models (CPE 4 mg/kg, RAA 0.7 mg/kg). It was unknown whether the 5-LO inhibition made any contribution to the anti-inflammatory activity of this compound. 

Oxicames are representatives of another series of anti-inflammatory, analgesic, and fever-reducing compounds whose mechanisms of action are most likely the suppression of prostaglandin synthesis. These drugs are capable of relieving painful symptoms of medium intensity. 

Literature reports on heterocyclic compounds containing a 1,2- or 2,1-benzothiazine ring have appeared in increasing numbers in recent years. This trend is likely to continue as a result of the anti-inflammatory activity of 4-hydroxy-2H-l,2-benzothiazine-3-carboxamide 1,1-dioxides (the oxicams ). 

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