Anti-hepatitis B agents

Zembower, D.E. and Zhang, H., Total synthesis of robustaflavone, a potential anti-hepatitis B agent, J. Org. Chem., 63, 9300, 1998. 

MODEL SYSTEMS FOR THE DISCOVERY AND EVALUATION OF POTENTIAL ANTI-HEPATITIS B AGENTS... 

Furman PA, Davis M, Liotta DC, Paff M, Frick LW, Nelson DJ, Dornsife RE, Wurster JA, Wilson LJ, Fyfe JA, Tuttle JV, Miller WH, Condreay L, Averett DR, Schinazi RF, Painter GR. The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and ( + ) enantiomers of cis-5-fluoro-l-[2-(hydroxymethyl)-l,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother 1992 36 2686-2692. 

Jacquard, A.-C., Brunelle, M.-N., Pichoud, C., et al. (2006) In vitro characterization of the anti-hepatitis B vims activity and cross-resistance profile of 2, 3 -didcoxy-3 -fluoroguanosine. Antimicrob. Agents Chemother., 50, 955-961. 

Ribozymes have been applied as anti-viral agents, for the treatment of cancer and genetic disorders, and as tools for pathway elucidation and target validation. Initial uses of ribozymes focused on anti-viral, primarily for the treatment of HIV (Rossi, 1999). Viruses that go through a genomic RNA intermediate in their replication cycle, such as HIV, hepatitis B virus and hepatitis C vims are attractive targets because a single... 

Since 2000, seven such agents have been approved for antiviral treatments covering anti-HIV, hepatitis B and cytomegalovirus (CMV). Rather than give details of each, we discuss below the importance of just two compounds of this class that would not have been synthesised without the historical perspective. 

Nucleosides are compounds exhibiting pharmacological activity of great interest [98,99] thus, some of these heterocyclic compounds have been used as anti-tumoral [100,101] or antiviral agents, including AIDS [102,103] and hepatitis B [104,105] treatments. 

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