Anti-carcinogenic activity

Zhang, Y., Kensler, T.W., Cho, C.G., Posner, G.H., and Talalay, P, Anti-carcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates, Proc. Natl. Acad. Sci. USA, 91, 3147-3150, 1994. 

The same group showed that e-allylselenocysteine (98), which is expected to yield allylselenol, a fairly hydrophobic metabolite, has more anti-carcinogenic power than 77 and propylselenocysteine (99) in rat methylnitrosourea model [233]. The diallyl selenide (106) has significant anti-carcinogenic activity using DMB-induced mammary tumor model and is 300 times more active than the diallyl sulfide, a flavor component of garlic [234]. 

At present the health risk of quercetin 38 for humans can not be estimated with confidence. The total amount of quercetin 38 ingested with the different therapeutically used Hypericum extracts is typically around 3 mg. Compared with the daily food intake, which is calculated to be about 50 mg [203, 204], the medical use of these preparations appears to represent a minimal additional hazard to human health. Moreover, there is even evidence that quercetin 38 possesses antimutagenic and anti carcinogenic activity [193,205]. 

Study of anti-carcinogenic activity of some retinoids and in the inhibition of carbonic-anhydrase (CA) by a series of sulfonamides are also presented in this chapter. 

The molecular size and shape descriptors may indicate if a ligand molecule, L, does not fit the active site. Unfortunately, in many cases the receptor site cannot be described in simple terms of large , width , and depth . The MTD (minimal topologic difference) method allows a receptor site mapping in the frame of a series of bioactive compounds. The MVD (minimal volume difference) method is an improved variant of the MTD method, which takes into account the 3D extension of a molecule. These two methods are described here in some detail. The results obtained in the study of anti-carcinogenic activity of some retinoids and in the inhibition of carbonic-anhydrase (CA) by a series of sulfonamides are also presented in this chapter. 

G is thought to be responsible for the anti-carcinogenic activity of China-rose hibiscus (Hibiscus rosa-sinensis) extract, and a recent study has shown that gentisic acid is a Fibroblast Growth Factor (FGF) inhibitor [60, 61]. 

Takasaki M, Konoshima T, Tokuda H, Masuda K, Aral Y, Shiojima K, Ageta H (1999) Anti-carcinogenic activity of Taraxacum plant. II. Biol Pharm Bull 22 606... 

Maoka, T., Tsushima, M., and Nishino, H. (2002) Isolation and characterization of dinochrome A and B, anti-carcinogenic active carotenoids from the fresh water red tide Peridinium bipes. Chem. Pharm. Bull., 50,1630-1633. 

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