Anti-amnesic

PEP(1470nM) [productsgive taste to tea] PEP inhibitors are potential anti-amnesics since PEP involved in metabolism of memory-linked vasopression, substance P thyrotropin releasing hormone (TRH)... 

Wang CM, Liu MY, Wang F, Wei MJ, Wang S, Wu CF et al (2013) Anti-amnesic effect of pseudoginsenoside-Fl 1 in two mouse models of Alzheimer s disease. Pharmacol Biochem Behav 106 57-67... 

Maurice, T., Lockhart, B.P., 1997. Neuroprotective and anti-amnesic potentials of sigma (s) receptor ligands. Prog. Neuro-Psychopharma-col. Biol. Psychiatry 21, 69-102. 

Documented effects Essential oils from this species are used in the pharmaceutical industry to add an aroma to drugs and in the fragrance industry as an aroma fixative (Khalmatov and Kosimov 1992 Ganunerman et al. 1990). Water and MeOH extracts of the plant strongly inhibited aldose reductase activity, an enzyme associated with diabetic complications (Kasimu et al. 1998). Compounds from the plant were found to inhibit prolyl endopeptidase (PEP), an enzyme thought to be involved with learning and memory processes, and the inhibition of which may produce anti-amnesic effects (Tezuka et al. 1999). 

Total Synthesis of (-)-Acutumine Castle and co-workers reported on the first total synthesis of (—)-acu-tumine 147 in 2009. " Isolated from Sinomenium acutum by Goto and Sudzuki in 1929, " this tetracyclic alkaloid is noted for its unique structural features that include a spiro-cyclic propellane-type system. This molecule also offers useful biological activities such as selective T-cell cytotoxicity and anti-amnesic properties. The synthetic route started from easily synthesizable starting materials chiral 143 and 144 to generate the precursor 145. The key step of the synthesis involves a one-pot ozonolysis-reductive amination on 145 to afford 146 (Scheme 39.43). 

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