Anti-amebic

Heterocycle-fused acridines possess a variety of biological activities, including Ca releasing, antiviral (e.g., anti-HIV), antimicrobial (e.g., anti-amebic and antiplasmodium) and antitumor properties. They are also enzyme inhibitors (e.g., topoisomerase II inhibitors and protein tyrosine kinase inhibitors) and have DNA-intercalation and metal-chelating properties. 

Dihydrochloride, C2aHMN202.2HCl, minute crystals, mp 209-210. Sol in water. therap CAT Anti-amebic. 

Crystals from banzene + Skellysolve A, mp 112.4-113.4". Slightly bitter taste. Very slightly sol in water sol in 95% ethanol to at least 5%. tmerap cat Anti amebic. 

Furoate, luramutt, Histomibal, Miforon, diloxanide 2-/u-roic acid ester. Do not confuse with the amide of furoic add. THERAP CAT Anti amebic. 

THERAP CAT (VET) Hydrochloride has been used as an anti-amebic and in Lung worm infection. 

Yellowish to pink powder. Dec on heating. Very slightly sol in water, alcohol. Practically insol in ether, chloroform, benzene. pH of satd aq soln 2.8-3.5. therap cat Anti-amebic. therap cat (VET) For trichomoniasis. 

Human Toxicity Has been linked with the occurrence of subacute myelo-optic neuropathy (S.M.O.N. syndrome) in Japan. T. Tsubaki etal., Lancet 1,696 (1971) see also ibid. 1, 534 (1977) J. Tateishi in Drug-Induced Sufferings, T. Soda, Ed. (Excerpta Medica, New York. 1980) pp 464-472. THERAP cat Topical anti-infective anti-amebic. therap cat (vet) Has been used as an intestinal anti-infective. 

Crystals from xylene. The medicinal grade is a yellowish -brown powder, mp 200-215 (extensive decompn). Almost insol in water sparingly sol in alcohol, ether, and acetone sol in hot pyridine and in hot dioxane. therap cat Anti-amebic. 

Crystals from methanol, mp 295 (dec). Speringly sol in water, alcohol sol in dil mineral acids. therap cat Anti -amebic. 

Crystals from ethyl acetate, mp 150.5-151. therap cat Anti-amebic. 

The preparation and the antiamebic activity of 1, 2 -secoemetlne (XIand styrylimidazole5 derivatives (XIl) have been reported. Dilox-anide (Xllla), one of the dichloroacetamide anti-amebic agents, appears to be dependent on the presence of viable bacteria for activity.5p... 

The results of clinical ials using combinations of anti-amebic drugs are encouraging. Powell5° concluded that acute amebic dysentery should be treated with a combination of a direct acting, systemically ef-fective amebacide (emetine preparations, q uinoline derivatives) and a broad spectrum antibiotic (tetracyclines). In this connection, the... 

T. is an antibiotic substance produced by Strepto-myces spp., e.g., Streptomyces viridifaciens fermentation with Streptomyces rimoses leads to 5-hydroxy-t. (= oxytetracycline), with Streptomyces aureofaciens, 7-chlorotetracycline (= aureomycine) is obtained. Its hydrochloride, the phosphate complex and its lauryl sulfate complex are used as antibacterials against gram-positive as well as gram-negative bacteria t. acts as an anti-amebic and anti-rickettsial agent. 

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