Acridines, heterocycle-fused

Acidity of azoles, basicity and, 41, 187 Acridines, heterocycle-fused, 70, 89 Acyl groups in heterocyclic compounds, conformations of, 41, 75 Acyclonucleosides, xeco-nucleosides, 67, 391 eco-nucleosides, 68, 1 tri-, tetra-, and penta-seco-nucleosides,... 

This review covers the following groups of heterocycle-fused acridines pyridoacridines, pyranoacridines, pyrroloacridines, thienoacridines, and furoacridines. 

Heterocycle-fused acridines possess a variety of biological activities, including Ca releasing, antiviral (e.g., anti-HIV), antimicrobial (e.g., anti-amebic and antiplasmodium) and antitumor properties. They are also enzyme inhibitors (e.g., topoisomerase II inhibitors and protein tyrosine kinase inhibitors) and have DNA-intercalation and metal-chelating properties. 

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