Anthranilic insecticidal activity

Figure 7 shows the relationship between insecticidal activity on Plutella xylostella and data from the Ca mobilization assay for a diverse structural set of anthranilic diamides. 

Table I. Insecticidal activity of Isomer A arylpyrazole anthranilic diamides of formula 12.

Table III. Insecticidal activity of aryl pyrimidine anthranilic diamides of formula 19.

Substituted arylpyrazole anthranilic diamides novel insecticidal activators of the ryanodine receptor (T. Selby, DuPont Crop Protection, USA)... 

DuPont has also introduced a new class of insecticides, the anthranilic diamides, such as DP-23 [205], which, like flubendiamide, also act by activating the ryanodine receptor [206],... 

The discovery of a novel class of anthranilic diamide insecticides having exceptional activity against a broad spectrum of Lepidoptera at extremely low rates of application has successfully led to the commercialization of Rynaxypyr (2). Compounds of this chemistry class exert their effect by causing release of intracellular Ca stores in muscle cells by activation of the ryanodine receptor. As a new mode-of-action product with outstanding insecticidal properties, Rynaxypyr offers great promise for the marketplace. 

The Novel Mode of Action of Anthranilic Diamide Insecticides Ryanodine Receptor Activation... 

Fluoro- and flnoroalkylpyrazole templates are also present in important agrochemicals, two examples being the marketed fungicide penthiopyrad [96] (Fig. 7a) and the insecticidal anthranilic diamide (Fig. 7b) [97]. Fnstero and co-workers prepared a small set of analogues of the commercially available acaricide tebufen-pyrad with several fluorinated side chains at the pyrazole C-3 [98]. Some of these compounds displayed higher acaricidal activity than the parent compound tebufen-pyrad (Fig. 7c). 

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