Anthranilate sunscreens

These sunscreen ingredients include octyl-dimethyl-PABA (UVB), 2-ethylhexyl-p-meth-oxycinnamate (UVB),octocrylene (UVA/UVB), octyl salicylate (UVB), benzophenones (UVB/ UVA), and methyl anthranilate (UVA). Avoben-zone or Parsol 1789 and mexoryl, a benzylidene camphor, block UVA. Mexoryl is the most efficient of the UVA organic sunscreens [10]. Many sunscreen formulations combine ingredients to maximize photoprotection. 

Another very common use of phenolic compounds is in sunscreens. The presence of the aromatic ring results in the effective absorbance of the UV-B radiation (between 280 and 315 nm) from the sun and thus prevents sunburns. The most common active ingredient in many sunscreens is p-aminobenzoic acid (PABA 7.1), which is actually not a phenolic compound. This compound has been widely used since the 1970 s but is less popular nowadays due to the formation of skin rashes and acne. As a result many sunscreens are now PABA-free. Alternative active ingredients include salicylates such as octylsalicylate (7.2), cinnamates such as octyl methylcinnamate (7.3), benzophenone (7.4) and the related compound oxybenzone (7.5), and anthranilates, such as menthylanthranilate (7.6). Octyl methylcinnamate (7.3) is insoluble in water and is therefore commonly... 

The kinetics of the addition of IV-acetyl-L-cysteine, N-acetylcysteamine, and N2-acetyl-L-lysine (NAL) to / -methoxycinnamate, / -methoxycinnamide, anthranilate, and crotonyl or sorboyl thiol ester have been studied, and the thiol addition products identified. The reaction rates increased at higher pH and the crotyl thiol ester was found to be 7.9 times more reactive than a sorboyl thiol ester toward IV-acetyl-L-cysteine addition. These unsaturated thiol esters may serve as a means of covalently binding UVA and UVB sunscreens to the outer layer of skin to provide long-lasting protection.128... 

Octyl methoxycinnamate Salicylates / Anthranilates Methyl salicylate Menthyl salicylate Menthyl anthranilate Octyl salicylate Physical Sunscreens... 

Use of UV absorbers or sunscreens in skin care products to prevent photo damage has been widely accepted. The common absorbers for UVB (280 to 320 nm) found in cosmetic products include PABA, salicylic acid derivatives, octocrylene, and phenylbenzimidazole sulfonic acid. Effective UVA (320 to 400 nm) absorbers include methyl anthranilate and avobenzone. Zinc oxide and titanium dioxide can physically block the radiation [74],... 

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