Anthelmintics diminished activity

Helminths, especially parasitic nematodes, cause severe health problems in humans and domestic animals. Although several classes of anthelmintics are commercially available, their suboptimal therapeutic spectrum and diminished activity due to the development of drug resistant... 

Glycine receptor function is modulated by alcohols and anesthetics [4]. Amino acid residue al(S267) is critical for alcohol potentiation, as mutation to small residues (Gly, Ala) enhance, and mutation to large residues (His, Cys, Tyr) diminish the ethanol effect. Glycine recqrtor modulation by Zn2+ involves structural determinants located within the large N-terminal domain. Additional glycinergic modulators include neuroactive steroids and the anthelmintic, ivermectin, which activates glycine receptors by a novel, strychnine-insensitive mechanism. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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