Cefpodoxime Antacids

CEFPODOXIME, CEFUROXIME ANTACIDS L levels of these antibiotics L absorption Take azithromycin at least 1 hour before or 2 hours after an antacid. Take these cephalosporins at least 2 hours after an antacid. Separate quinolones and antacids by 2-6 hours. Separate tetracyclines and antacids by 2-3 hours... 

Saathoff N, Lode H, Neider K, Depperman KM, Borner K, Koeppe P. Pharmacokinetics of cefpodoxime proxetU and interactions with an antacid and an H2 receptor antagonist. Antimicrob Agents Chemother 1992 36(4) 796-800. 

No clinically significant interactions appear to occur between an aluminium/magnesium hydroxide antacid and cefaclor AF, ce-falexin, cefetamet pivoxil, cefixime or cefprozil between Alka-Seltzer and cefixime or between ceftibuten and Mylanta. In contrast, antacids reduce the bioavailability of cefpodoxime proxetil. 

A study in 10 healthy subjects found that 10 mL of an aluminium/magnesium hydroxide antacid (Maalox) reduced the bioavailability of cefpodoxime proxetil by about 40%. This was considered to be due to reduced dissolution at increased gastric pH values. These results confirm the findings of a previous study with sodium bicarbonate and aluminium hydroxide. It has been recommended that cefpodoxime is given at least 2 hours after antacids. ... 

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