Anticholinergic drugs animal studies

The data Include protocols of military experloience declassified for this review, reports published in the scientific literature on animals and man, and my own studies. Between 1956 and 1966, experiments were undertaken in my laboratories in New York and St. Louis to define the effects of anticholinergic drugs on brain function and behavior. He sought to determine whether ai of the substances had persistent behavioral effects chat could be useful in treating the severely mentally ill (1-7). 

It can be concluded from such structure-activity studies, which are based on extensive psychopharmacologlc stests in both animals and human volunteers, that BZ is the most representative of the most potent anticholinergics. However, atropine and methylatropine are the most representative of the relatively Inactive anticholinergics and could serve as control drugs, particularly because atropine is equlpotent, although of shorter duration, to BZ in peripheral anticholinergic effects. 

Pharmacological studies (5-7) indicate that Trithiozine (T) possesses considerable antisecretory and antiulcer activity, at the dose of 25-100 mg/kg per os, on different animals, while it is devoid of anticholinergic, antihistaminic, ganglioplegic and cardiovascular effects. The drug also has a mild tranquillizing action and a very low toxicity in various animal species. 

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