Animal models selective breeding

Overstreet DH, Russel RW, Helps SC, Messenger M (1979) Selective breeding for sensitivity to the anticholinesterase, DFP. Psychopharmacology (fieri) 65 15-20 Overstreet DH, Rezvani AH, Janowsky DS (1992) Mandsley reactive and nonreactive rats differ only in some tasks reflecting emotionality. Physiol Behav 52 149-152 Overstreet DH, PncUowski O, Rezvani AH, Janowsky DS (1995) Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders sensitive line rats as an animal model of depression. Psychopharmacology (Berl) 121 27-37... 

Chapman KP, Stafford WW, Day CE (1976) Produced by selective breeding of Japanese quail animal model for experimental atherosclerosis. In Day CE (ed) Atherosclerosis Drug Discovery. Plenum Press, New York, London, pp 347-356... 

We have been interested in the effect of poly(ADP-ribosyl)ation on chemical carcinogenesis in vivo. The system used was the induction of hepatocarcinogenesis by methylazoxymethanol acetate (MAM acetate) in the small fish Medaka", Oryzias latipes. Medaka was selected as a suitable model animal for the following reasons It is easy to breed, adapts to a wide range of temperatures, is easy to sexually differentiate, has a short reproductive cycle, and is available as a pure strain. In addition, continuous administration to Medaka of the drug is possible by simply dissolving it in tank water. 

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