Animal Models of Disease for Future Toxicity Predictions

ANIMAL MODELS OF DISEASE FOR FUTURE TOXICITY PREDICTIONS 

Animal models of human disease are commonly utilized in early discovery studies, either in elucidation of the pathogenesis of the disease or the potential for a particular compound to provide a therapeutic benefit. However, animal models of human disease are relatively rarely utilized in nonclinical safety testing instead, conventional (healthy) rodent and nomodent models are typically utilized. This chapter will 

As will be discussed in the following sections, there are various diseased animal models, including spontaneous, chemically/surgically induced, or genetically engineered models for academic and pharmaceutical research applications. However, details of each existing or newer models are outside the scope of this chapter. Key perspectives discussed include strengths and weaknesses of commonly used animal models, potential causes/factors for poor translation of safety liabilities from animals to humans, and their application in the nonclinical mechanistic and safety studies. 

Drug Discovery Toxicology From Target Assessment to Translational Biomarkers, First Edition. Edited by Yvonne Will, J. Eric McDufSe, Andrew J. Olaharski, and Brandon D. Jeffy. 

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ANIMAL MODELS OF DISEASE FOR FUTURE TOXICITY PREDICTIONS TABLE 18.6 Models of Acute Lung Injury"... 

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