Animal models coagulation factors

Studies have indicated that leukocytes play a critical role in the activation of coagulation in patients with septicemia and in animal models of acute lung injury (69). One study has presented direct evidence indicating the role of tissue factor expression on activated endothelial cells on in vivo thrombogenesis (70). 

TFPI, when administered to rabbits, has been shown to have an antithrombotic effect when thromboplastin was used as a thrombogenic challenge (I 10). TFPI was also shown to be an effective inhibitor when thrombosis was induced in rabbit jugular veins by endothelial destruction and restricted blood flow. The antithrombotic and antiprotease actions of TFPI have been tested in several other animal models. Warn-Cramer et al. investigated the effect of immunodepletion of TFPI in factor Vila and Xa induced coagulation in rabbits (III). These rabbits were observed to be sensitized to the procoagulant effects of factor Vila, but not factor Xa in the absence of factor Vila. Two studies have indicated that TFPI administration reduces the lethal effects of . coli administration in a septic shock model in baboons (I 12). These studies also indicated that TFPI may have an anti-inflammatory effect, as an attenuation of the IL-6 response was also observed. Administration of TFPI has been observed to prevent... 

As mentioned above, preclinical pharmacology and toxicology for plasma derivatives has not included preclinical assessments commonly employed for small-molecule drug products. Most preclinical development involves comparative pharmacokinetics and the use of animal models has been an important component of this evaluation. The coagulation factors have shown the potential for efficacy in animal models such as the von Willebrand swine and hemophilic dog [16,17],... 

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