Animal hemoglobin

D8. Dozy, A. M., Kleihauer, E. F., and Huisman, T. H. J., Studies on the heterogeneity of hemoglobin. XIII. Chromatography of various human and animal hemoglobin types of DEAE-Sephadex. J. Chromalogr. 32, 723-727 (1968). 

Dll. Drysdale, J. W., Righetti, P., and Bunn, H. F., The separation of human and animal hemoglobins by isoelectric focusing in polyacrylamide gel. Biochim. Bio-phys. Acta 229, 42-50 (1971). 

Schroeder, W. A., and Jones, R. T., Some aspects of the chemistry and function of human and animal hemoglobins. Fortschr. Chem. Org. Naturst. 23, 113-194 (1965). 

Metabolism releases CO2, which reduces the pH of the fluid around the cell and must be buffered for metabolism to continue. In animals, hemoglobin and other blood proteins play an important role in this buffering. 

Very few biological materials have been analyzed for the presence of MBOCA or its metabolites. MBOCA and its metabolites have been measured in urine of exposed humans and experimental animals. Hemoglobin adducts have also been measured in the blood of exposed animals. The most frequently used techniques are gas chromatography (GC) with electron capture detection (ECD) and high-performance liquid chromatography (HPLC) with electrochemical detection (ED). Detailed methodologies from selected studies are presented in Table 6-1. 

Zuckerkandl, E., R.T. Jones, and L. Pauling A comparison of animal hemoglobin by tryptic peptide pattern analysis. Proc Nat Acad Sci USA 46 1349, 1960. 

A comparison of animal hemoglobins by tr5T)tic peptide pattern analysis. Proc. Natl. Acad. Sci. 46 (1960) 1349-1360. (Emile Zuckerkandl, Richard T. Jones, and Linus Pauling). SP 118 ... 

In human beings and most animals, hemoglobin is found in the blood and gives blood its characteristic color. (In those species without hemoglobin, the blood is either a different color or colorless.) A vastly oversimplified representation of respiration is given in Equation (6.19) ... 

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