Angiotensins structure-activity

Mayer, D., Naylor, C.B., Motoc, I., Marshall, G.R. Aunique geometry of the active site of angiotensin-converting enzyme consistent with structure-activity studies./. Comput.-Aided Mol. Des. 1987, 3(1), 3-16. 

Yanagisawa H, Amemiya Y, Kanazaki T, Shimoji Y, Fujimoto K, Kitahara Y, Sada T, Mizuno M, Ikeda M, et al. Nonpeptide angiotensin II receptor a ntago-nists synthesis, biological activities, and structure-activity relationships ofimi-dazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds./. Med. Chem., 1996, 39, 323-338. 

Waller, C.L. and Marshall, G.R. (1993) Three-dimensional quantitative structure-activity relationship of angiotensin converting enzyme and thermolysin inhibitors. 2. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active analog and complementary receptor field alignment rules. J. Med. Chem., 36, 2390-2403. 

Wu, J. and Aluko, R.E. (2007) Quantitative structure-activity relationship study of bitter di- and tripeptides including relationship with angiotensin I-converting enzyme inhibitory activity./. Pestic. Sci., 13, 63-69. 

N. Rankine, J. M. Revill, D. A. Roberts, and S. T. Russell, /. Med. Chem., 35,4027 (1992). New Nonpeptide Angiotensin II Receptor Antagonists. 2. Synthesis, Biological Properties, and Structure-Activity Relationships of 2-Alkyl-4-(biphenylylmethoxy)quinoline Derivatives. P. Biihlmayer, L. Criscione, W. Fuhrer, P. Furet, M. de Gasparo, S. Stutz, and... 

A Unique Geometry of the Active Site of Angiotensin-Converting Enzyme Consistent with Structure—Activity Studies. 

Novel ATj-selective angiotensin II receptor antagonists (111) have been prepared and structure-activity relationships in this series have been established [93MI(3)2023]. 6-(l -Imidazol-l-yl)-7-nitro-2,3(l/f,4//)-quinoxalinedione hydrochloride (YM90K) and related compounds 112 have been nthesised as novel antiepileptic agents (94JMC(37)4671. 

D. Mayer, C. B. Naylor, 1. Motoc, and G. R. Marshall,/. Comput.-Aided Mol. Design, 1,3 (1987). A Unique Geometry of the Active Site of Angiotensin-Converting Enzyme Consistent with Structure Activity Studies. 

A.R De Arriba, L.A. Gomez-Casajus, F. Cavalcanti, C. Almansa, J. Garcia-Rafanell, J. Fore, Synthesis and structure-activity relationship of a new series of potent ATj selective angiotensin II receptor antagonists 5-(biphenyl-4-yhnethyl)pyrazoles, J. Med. Chem. 40 (1997) 547-548. 

All = angiotensin II APA = anilinophenylacetamide 3D = three-dimensional MMFF = Merck macromolecular force field SAR = structure-activity relationship SPERM superposition by permutation. 

Angiotensin 11 the potent vasoconstrictor and pressor octapeptlde released from a plasma a2-globulln by the kidney enzyme, renin, continues to receive considerable research attention. A comprehensive review of the chemistry, structure-activity relationships and biology of the renin-angiotensin system has just become available. The structure of human angiotensin II was reported to be identical to that of horse (lie in position 5 rather than V il for bovine). Several radioimmunoassays have been reported ... 

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