Angiotensin Il-induced hypertensive

Burke SL, Evans RG, Moretti JL, Head GA. Levels of renal and extrarenal sympathetic drive in angiotensin Il-induced hypertension. Hypertension. 2008 51 878-883. 

Weiss, D., Kools, J. J., and Taylor, W. R. 2001. Angiotensin Il-induced hypertension accelerates the development of atherosclerosis in apoE-deficient mice. Circulation 103 448-454. 

Diep, Q.N., El Mabrouk, M., Yue, P., and Schiffrin, E.L. 2002. Effect of ATi receptor blockade on cardiac apoptosis in angiotensin Il-induced hypertension. Am. J. Physiol. 282 H1635-H1641. 

Zhang, Y., Griendling, K.K., Dikalova, A., Owens, G.K., and Taylor, W.R. 2005. Vascular hypertrophy in angiotensin Il-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2. Hypertension 46 732-737. 

Hori K, Suzuki M, Tanda S, Saito D, Shinozaki M, Zhang QH. Fluctuations in tumor blood flow under normotension and the effect of angiotensin Il-induced hypertension. Jpn J Cancer Res 1991 82 1309-1316. 

Diz, D.I., Baer, P.G. and Nasjletti, A. (1983). Angiotensin Il-induced hypertension in the rat. Effects on the plasma concentration, renal excretion, and tissue release of prostaglandins. ]. Clin. Invest., 72, 466-477... 

Zhang, J., L. Vfllacorta, L. Chang et al. 2010. Nitro-oleic acid inhibits angiotensin Il-induced hypertension, 107 (4) 540-8. 

Sarr M, Chataigneau M, Martins S, Schott C, El Bedoui J, Oak MH, Muller B, Chataigneau T, Schini-Kerth VB (2006) Red wine polyphenols prevent angiotensin Il-induced hypertension and endothehal dysfunction in rats role of NADPH oxidase. Cardiovasc Res 71(4) 794-802... 

Dal-Ros S, Bronner C, Schott C, Kane MO, Chataigneau M, Schini-Kerth VB, Chataigneau T (2009) Angiotensin Il-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery. J Pharmacol Exp Ther 328(2) 478 86... 

Captopril, as well as other ACE inhibitors, is indicated in the treatment of hypertension, congestive heart failure, left ventricular dysfunction after a myocardial infarction, and diabetic nephropathy. In the treatment of essential hypertension, captopril is considered first-choice therapy, either alone or in combination with a thiazide diuretic. Decreases in blood pressure are primarily attributed to decreased total peripheral resistance or afterload. An advantage of combining captopril therapy with a conventional thiazide diuretic is that the thiazide-induced hypokalemia is minimized in the presence of ACE inhibition, since there is a marked decrease in angiotensin Il-induced aldosterone release. 

Murasawa, S., Mori, Y., Nozawa, Y., Masaki, H., Maruyama, K., Tsutsumi, Y., Moriguchi, Y., Shibasaki, Y., Tanaka, Y., Iwasaka, T., Inada, M., and Matsubara, H. 1998b. Role of calcium-sensitive tyrosine kinase Pyk2/CAK 3/RAFTK in angiotensin Il-induced Ras/ERK signaling. Hypertension 32 668-675. 

Zafari, A.M., Ushio-Fukai, M., Akers, M., Yin, Q., Shah, A., Harrison, D.G., Taylor, W.R., and Griendling, K.K. Role of NADH/NADPH oxidase-derived H202 in angiotensin Il-induced vascular hypertrophy. Hypertension 1998 32 488-95. 

Losartan blocks the vascular constrictor effect of Ang II, the Ang Il-induced aldosterone synthesis and/or release, and the All-induced cardiovascular growth. In various models of experimental hypertension, losartan prevents or reverses the elevated blood pressure and the associated cardiovascular hypertrophy similar to angiotensin converting enzyme (ACE) inhibitors. Subsequently con-tolled clinical trials revealed that losartan is a new and valuable drug for treatment of hyper-... 

---