Angiotensin II analog

Vine, W. H., Brueckner, D. A., Needleman, P. and Marshall, G. R. (1973) Synthesis, biological-activity, and F-19 nuclear magnetic resonance spectral of Angiotensin-II analogs containing fluorine. Biochemistry, 12(8), 1630-1637. 

A series of angiotensin II analogs have been synthesized by Fessler using an SP procedure and screened as antagonists of angiotensin II on vascular smooth muscle. These included QAsn, Val , Abu ] angiotensin II and all were found to be potent inhibitors of the vascular effects of angiotensin II. 

An analogy may be drawn between the proxiirml kidney tubule and thaproximal intestines. Here, angiotensin II directly stimulates Na reabsorption. An analogy may also be made between the distal tubule and the distal intestines. Here, aldosterone... 

Dipeptidyl carboxypeptidases remove the C-terminal dipeptide intact and therefore are analogous to the dipeptidyl aminopeptidases such as cathepsin C. One such enzyme, angiotensin-converting enzyme, is important biologically for converting angiotensin I into the hypertensive angiotensin II (see Section 9.3). This enzyme does not hydrolyse bonds of the type X—Pro but will hydrolyse Pro—X bonds. The use of dipeptidyl carboxypeptidases for sequence determination would probably increase if pure enzymes were readily available commercially. 

Figure 6.2). All the compounds show similar structures and similar affinity for the angiotensin II receptor. As such they can be considered as full analogs. 

Angiotensin II. Angiotensin II and its analogs are potent regulators of PGE production in the rat epididymis, suggest-... 

C. L. Waller and G. R. Marshall, J. Med. Chem., 36,2390 (1993). 3D-QSAR of Angiotensin-Converting Enzyme and Thermolysin Inhibitors. II. A Comparison of CoMFA Models Ineorporating Molecular Orbital Fields and Desolvation Free Energies Based on Active-Analog and Complementary-Receptor-Field Alignment Rules. 

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