Angiotensin adrenal medulla

Angiotensin II, acting at presynaptic receptors on noradrenergic nerve terminals, potentiates the release of norepinephrine during low-frequency sympathetic nerve stimulation. Aside from its action on the nerve terminals of postganglionic sympathetic neurons, angiotensin II can directly stimulate sympathetic neurons in the central nervous system, in peripheral autonomic ganglia, and at the adrenal medulla. 

Angiotensin II also interacts with the autonomic nervous system. It stimulates autonomic ganglia, increases the release of epinephrine and norepinephrine from the adrenal medulla, and—what is most important—facilitates sympathetic transmission by an action at adrenergic nerve terminals. The latter effect involves both increased release and reduced reuptake of norepinephrine. Angiotensin II also has a less important direct positive inotropic action on the heart. 

Adrenal medulla. Angiotensin is a powerful releasing agent of catecholamines from the adrenal medulla as reported by Feldberg and Lewis and by other authors (see 33),... 

The great interest devoted to the action of angiotensin is mainly due to the rdle that this peptide could play in the pathogenesis of hypertensive disease. The sites of action of angiotensin are numerous since the peptide mimics the motor actions of either adrenaline or acetylcholine. Such actions are due either to a direct stimulation of the effector cell or to an indirect one by increased activity of the neurovegetative system. Furthermore, angiotensin elicits metabolic and renal effects and stimulates the adrenal medulla. 

Feldberg, W., and Lewis, G. P., 1964, The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin, /. Physiol. 171 98. 

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