Angiogenic vessels

ISO.Asai T et al (2002) Anti-neovascular therapy by liposomal DPP-CNDAC targeted to angiogenic vessels. FEBS Lett 520 167-170... 

Key words Oligopeptides, Liposomes, Polyethyleneglycol, Angiogenic vessels, APRPG... 

Asai T, Miyazawa S, Maeda N, Hatanaka K, Katanasaka Y, Shimizu K, Shuto S, Oku N (2008) Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC. Cancer Sci 99 1029-1033... 

T. Asai, K. Shimazu, M. Kondo, K. Kuromi, K. Watanabe, K. Ogino, T. Taki, S. Shuto, A. Matsuda, and N. Oku Anti-neovascular therapy by bposomal DPP-CNDAC targeted to angiogenic vessel. FEBS Letters 520 (2002) 167-170. 

Stacker The vessels that are recruited or at least expand in the rejection process have strong expression of markers for lymphatic vessels. It was previously thought there was an infiltration of angiogenic vessels, and this was part of the rejection process. It appears now as though a high proportion of those vessels have lymphatic markers and appear to be behaving as lymphatic vessels. This is only one of a few immune regulated model that has been reasonably studied, apart from the tumour models which have been well characterized. 

Shimizu K, Sawazaki Y, Tanaka T, Asai T, Oku N. Chronopharmacologic cancer treatment with an angiogenic vessel-targeted liposomal drug. Biol Pharm Bull 2008 31 95-98. 

Drug targeting to angiogenic vessels using peptide motifs... 

A new application of the technique of intravital microscopy to tracheal vessels has been demonstrated in rats (14,15). Shown in Fig. 15.3 is a still image taken from the videotaping of a postcapillary venule of a rat. Several adherent leukocytes are evident. Recruitment in real time can be evaluated, as can alterations in the permeability of different-sized fluorescent dextrans. Vaso-motion as assessed by vessel diameters and red blood cell velocity can also be measured. This in vivo imaging approach can be used for a functional assessment of angiogenic vessels of large airways. 

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