Angiogenic/Angiogenesis inhibitor

The corneal pocket assay and the window preparations are designed to measure vessel formation after addition of stimulators. These assays can for instance be used for the study of angiogenic potential of human tumours. These models are also suitable for pre-clinical testing of angiogenesis inhibitors. 

GBM, among the most angiogenic of all neoplasms, represents a natrual target for angiogenesis inhibitors. 

Wakabayashi, T. et al., Borrelidin is an angiogenesis inhibitor disruption of angiogenic capillary vessels in a rat aorta matrix culture model, J. Antibiot. (Tokyo), 50, 671, 1997. 

The CXC chemokines can be divided into two groups on the basis of a structure/function domain consisting of the presence or absence of three amino acid residues (Glu-Leu-Arg ELR motif) that precedes the first cysteine amino acid residue in the primary structure of these cytokines. The ELR+ CXC chemokines are chemoattractants for neutrophils and act as potent angiogenic factors (6). In contrast, the ELR" CXC chemokines are chemoattractants for mononuclear cells and are potent inhibitors of angiogenesis (Table 1) (6). 

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