VEGF-induced angiogenesis

Although adenosine may contribute rather little to the increase in VEGF induced by hypoxia, it may contribute as much as 50% to angiogenesis (Adair 2005 Auchampach 2007). This could mean that adenosine acts also independently of VEGF, something that is not unlikely given the involvement of multiple cell types and multiple angiogenetic factors. 

I Pearlman JD, Hibberd MG, Chuang ML, et al. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nat Med 1995 I (10) 1085-1089,... 

Eliceiri, B. P., Paul, R., Schwartzberg, P. L., Hood, J. D., Leng, J., and Cheresh, D. A. 1999. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell. 4 915-924. 

Activated VEGFR1 alone, however, has relatively weak tyrosine kinase activity and may be insufficient to stimulate endothelial cell proliferation [20]. On the other hand, inhibition of angiogenesis by factors such as pigment epithelium-derived factor (PEDF) is associated with reduced VEGF-induced phosphorylation of VEGFR1 [23],... 

VEGF-RTK [VEGF induced by ischaemia hypoxia VEGF induces angiogenesis]... 

Angiogenesis Prophylactic treatment with ATL-1 protected against angiogenesis and CD-31 expression in a murine air pouch model of angiogenesis ATL-1 potently inhibits endothelial cell proliferation ATL-1 inhibits VEGF-induced endothelial cell chemotaxis Fierro et al 2002 Fierro et al 2003... 

HIF-1 Dependent and Independent Pathways for VEGF-Induced Angiogenesis... 

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