Angiogenesis inhibitory activity

Lu, J., Zhang, K., Nam, S., Anderson, R.A., Jove, R., and Wen, W. 2010. Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. Carcinogenesis, 31(3), 481 88. 

Novel angiogenesis inhibitory activity in ciimamon extract blocks VEGFR2 kinase and downstream signaling. 2010. Carcinogenesis, 3P. 481 88. 

Activation and differentiation of cytotoxic T lymphocytes (CD8+ T cells) (CTLs) require interplay of various cytokines and cells. During the presentation of tumor-specific antigens by antigen-presenting cells (APCs) to helper T cells (CD4+ T cells), cytokines present in the microenvironment control the helper immune response to develop into either a cellular or a humoral response. CD4+ T cells have been classified into Thl and Th2 subsets according to the pattern of cytokines they produce. Thl clones secrete IL-12 and IFN-y, whereas Th2 clones secrete IL-4, IL-5, IL-6 and IL-10. Thl immune response is beneficial for the development of the cellular cytotoxic (CD8) immune response, whereas Th2 immune response is inhibitory to cytotoxic response. IFN-y is a type 1 interferon that also promotes Thl-type anti-tumor immunity, reduces tumor cell growth, and inhibits angiogenesis. 

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