Anexate - Flumazenil

Fertinex urofollitropin flumazenil Anexate, Lanexat, Romazicon... 

This is a strong sedative with a short onset of action that can be administered intravenously, rectally, intramuscularly or sublingually. Midazolam can be used as premedication 4 or 5 drops are given sublingually as soon as the patient arrives at the clinic. It has a short half-life. The anesthetist injects a dose of 1 mg intravenously under pulse oximeter monitoring, even if the risk of respiratory depression is very rare with a 5 mg dose. In case of overdose, flumazenil (Anex-ate , which comes in 1 mg/10 ml phials) takes less than 1 minute to compete with the central receptors occupied by the midazolam 0.2 ml is injected intravenously (15 seconds). Additional doses of 1 ml can be reinjected every minute until the patient regains consciousness. Flumazenil has very low toxicity, and doses of up to 100 mg have been injected intravenously without any signs of overdose. 

Zuber M, Elsasser S, Ritz R, Scollo-Lavizzari G. Flumazenil (Anexate) in severe intoxication with carbamazepine (Tegretol). Eur Neurol 1988 28(3) 161-3. 

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