Androgens, Hershberger assay

Yamada T, Ueda S, Yoshioka K et al (2003) Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotropic and Hershberger assays. Toxicology 186 227-239... 

Newly proposed test guidelines to specifically address effects on hormone homeostasis and on male and female reproductive organs include the rodent uterotrophic assay to detect estrogenic effects (OECD 2007a) and the rodent Hershberger assay to detect androgenic effects (OECD 2007b). 

Sunami, O., Kunimatsu, T, Yamada, T. Yabushita, S., Sukata, T, Miyata, K.. Kamila. Y., Okuno, Y., Seki, T., Nakatsuka. I., and Matsuo, M. (2000). Evaluation of a 5-day Hershberger assay using young mature male cats Methylte.sto.s(cronc and p./j -DDK, but not fenitrothion. exhibited androgenic or antiandrogenic activity i vivo. J. Toxicol. Sci. 25,403-415. 

Kunimatsu T, Yamada T, Ose K et al (2002) Lack of (anti-)androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays. Regul Toxicol Pharmacol 35 227-237... 

Ashby, J., and Lefevre, P, A. (2000). The peripuberial male rat a.s.say as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oesirogens and metabolic modulators. J. Appl To.xicol 20, 35-47. 

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