Allergic drug reactions anaphylaxis

This was her first exposure to cetirizine or any other piperazine derivative, and on recovery she reported no previous history of allergic drug reactions or concomitant use of any other medication or alcohol [3 ]. Although fixed drug eruptions have been previously reported with both cetirizine and levocetirizine [SEDA-31, 30] anaphylaxis caused by systemic antihistamines is very rare, particularly in the absence of known previous exposure. The authors speculated that the potential antigenic nature of the piperazine ring may have been a factor [4 ]. 

Sicherer SH, Leung DY Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. J Allergy Clin Immunol 2005 116 153. [PMID 15990789]... 

Examples Allergic rhinitis, asthma, systemic anaphylaxis Some drug allergies (eg.. penicillin) Serum sickness, Arthus reaction Tuberculin reaction, contact dermatitis (with IVc) Chronic asthma, chronic allergic rhinitis Maculopapular exanthema with eosinophilia Contact dermatitis, Maculopapular and bullous exanthema, hepatitis AQEP Beh t disease... 

Aspirin and NSAIDs can induce allergic and pseudoallergic reactions. Because these drugs are used so widely, with much over-the-counter use, the health care professional must have a basic understanding of the types of reactions that can occur and how to prevent them. Three types of reactions occur bron-chospasm with rhinoconjunctivitis, urticaria/angioedema, and anaphylaxis. Remember that patients with gastric discomfort... 

---