Analytes - Negatively Charged Chiral Selectors

Cationic Analytes - Negatively Charged Chiral Selectors 

SIM positive ion mode (4 ions) capillary voltage, 3 kV fragmentor, 70 V drying gas Nj, flow and temperature, 5 L min and 150 °C nebulizer pressure 4 psi sheath liquid, 0.5% formic acid in water-isopropanol (50/50,v/v) sheath flow, 3 pL min .  

---

Lammerhofer and Lindner [90] explained the chiral resolution of N-derivatized amino acids by CEC. The authors explained the formation of the transient diastereomeric ion-pairs between negatively charged analyte enantiomers and a positively charged chiral selector by multiple intermolecular interactions which might be differentially adsorbed to the ODS stationary phase. Furthermore, they claimed that the enantioseparation was achieved because of different observed mobilities of the analyte enantiomers originating from different ion-pair formation rates of the enantiomers and/or differential adsorption of the diastereoisomeric ion-pairs to the ODS stationary phase [90]. 

---