Analogue identification

Datta-Mannan A, Stone MJ. Chemokine-binding specificity of soluble chemokine-receptor analogues identification of interacting elements by chimera complementation. Biochemistry 2004 43 14602-11. 

Mundall E. C., Szibbo C. M. and Tobe S. S. (1983) Vitellogenin induced in adult male Diploptera punctata by juvenile hormone and juvenile hormone analogue identification and quantitative aspects. J. Insect Physiol. 29, 201-207. 

Figure 11.12 GC analysis of (a) urine sample spiked with opiates 3 p.g/ml) and (b) blank urine sample. Peak identification is as follows 1, dihydrocodeine 2, codeine 3, ethylmor-phine 4, moipliine 5, heroin. Reprinted from Journal of Chromatography, A 771, T. Hyotylainen et al., Determination of morphine and its analogues in urine by on-line coupled reversed-phase liquied cliromatography-gas clrromatography with on-line derivatization, pp. 360-365, copyright 1997, with permission from Elsevier Science.

Similar observations were made when BrCN was replaced by C1CN. Then the chlorine analogue S-60 was observed. Probably we were also successful in transferring photochemically both isocyanocarbenes 58 and 60 into the corresponding halogenated cyanocarbenes. But their identification has to remain tentative, since only two IR bands could be found for each of the new cyano carbenes. 

The sarcoplasmic reticulum (SR) was first identified as the major mobilizable intracellular store of Ca2+ in skeletal muscles through the work of S. Ebashi, W. Hasselbach and A. Weber (review in Ebashi 1991). Identification of the SR and its role in smooth muscle met some early difficulties, partly due to the destructive effects of osmium fixation. Eventually the SR of smooth muscle was also identified, quantitated and its spatial distribution, peripheral and central, determined (Somlyo et al 1971, Devine et al 1971). Strontium (Sr), used as an electron opaque analogue of Ca2+, permitted direct, electron microscopic visualization of divalent cation transport into the SR (Somlyo Somlyo 1971). 

K., Wachter, H., Werner-Felmayer, G., Mayer, B., Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synthase, Biochem. J. 320 (1996), p. 193-196... 

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