Amyotrophic lateral sclerosis riluzole

Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V (1996) Dose ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet 347 1425-1431. 

Amyotrophic lateral sclerosis Riluzole, antisecretory medication, supportive care Weakness, drooling... 

Morrison KE. Therapies in amyotrophic lateral sclerosis - beyond riluzole. Curr Opin Pharmacol 2002 2 302-9. 

Amyotrophic lateral sclerosis (ALS) is a progressive, usually fatal, neurodegenerative disease caused by the degeneration of motor neurons in the central nervous system. No cure has yet been found for ALS. The U.S. Food and Drug Administration (FDA) has approved riluzole as the first drug treatment for the disease. It delays the onset of ventilator-dependence or tracheostomy in selected patients. A Cochrane review states a 9% gain in the probability of surviving one year (see Miller et ah, 2007). 

Bruno V, Battaglia G, Copani A, et al (2001) Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood FlowMetab 21 1013-1033 Bryson HM, Fulton B, Benfield P (1996) Riluzole—a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis. Drugs 52 549-563... 

Gurney ME, Fleck TJ, Himes CS, Hall ED (1998) Riluzole preserves motor fimction in a transgenic model of familiar amyotrophic lateral sclerosis. Neurology 50 62-67 Haines DR, Gaines SP (1999) N of 1 randomised controlled trials oforal ketamine in patients with chronic pain. Pain 83 283-287... 

Desnuelle C, Dib M, Garrel C, Eavier A (2001) ALS Riluzole-Tocopherol Study Group. A double blind, placebo controlled randomized clinical trial of alpha tocopherol in the treatment of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2(1) 9-18. 

Amyotrophic lateral sclerosis is currently treated with riluzole, which improves survival in 30% of patients. Riluzole, an NMDA receptor antagonist, is discussed later in this chapter. A clinical trial of gabapentin, a (y aminobutyric acid (GABA) agonist, in amyotrophic lateral sclerosis demonstrated little efficacy. Antioxidants have also not demonstrated significant efficacy so far. 

Riluzole is an NMDA antagonist with actions at the pre- and postsynaptic levels. It is currently being used in amyotrophic lateral sclerosis patients. Riluzole also inhibits glutamate-induced convulsions. Several riluzole analogs have been synthesized and tested for inhibition of glutamate-induced seizures (44). The trifluoromethoxy side-chain can be re-... 

M. E. Gurney, F. B. Curring, R Zhai, and others Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Annals of Neurology 39, 147 (1996). 

Taxane for breast cancer (second line) 15,250 Riluzole for amyotrophic lateral sclerosis (Lou Gehrig s disease) 38,750... 

Bensimon, G., Lacomblez, L., Meininger, V., and the ALS/Riluzole Study Group. (1994). A controlled trial of riluzole in amyotrophic lateral sclerosis. N. Engl. J. Med. 330 585-591. 

Benesimon G, Lacomblez L, Meininger V (1994) A controlled trial of riluzole in amyotrophic lateral sclerosisALS/Riluzole Study Group. N Engl J Med 330 585-591 BUsland LG, Greensmith L (2008) The endocannabinoid system in amyotrophic lateral sclerosis. CurrPharmDes 14 2306-2316... 

The benzothiazole heterocycle is also found in a variety of pharmaceutical agents. For example, anthelmintic activity is exhibited by tioxidazole and ffentizole, both possessing benzothiazole. Fostedil is a calcium channel blocker that shows vasodilator activity. " Riluzole is another benzothiazole-containing molecule that has found use in the treatment of amyotrophic lateral sclerosis, where it delays progression of the disease thereby prolonging life. ... 

Benzothiazoliums are also a part of many important dyes (Svetlichnyi et al. 2007) e.g Cyanine Dyes, Thioflavin T S, (Stsiapura et al. 2007) (Sabate Saupe 2007) Direct yellow 7, Camotine, Primuline, etc. In medicine the benzothiazolium salts play an important role, for example Riluzole a benzothiazole-based drug is used to treat amyotrophic lateral sclerosis. (Kitzman 2009). 

R. G. Miller, J. D. Mitchell, M. Lyon, and D. H. Moore. Riluzole for amyoteophic lateral sclerosis (ALS)/motor neuron disease (MND). Amyotroph.Lateral.Scler.Other Motor Neuron Disord. 4 (3) 191-206,2003. 

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