Amyloidosis Spleen

AA amyloid appears in a generalized form and is mainly stored perireticularly in the kidney, spleen and liver. This kind of amyloidosis occurs as (1.) a congenital form in cases of familial Mediterranean fever, (2.) an idiopathic (= primary) form without any associated basic disease, and (i.) a reactive (= secondary) form in chronic inflammations or tumours (e.g. Hodgkin s disease) as well as in drug abuse and AIDS. 

Straub, R.F., Boyer, T.D. The liver-spleen scan in systemic amyloidosis a clue to the diagnosis. J. Clin. Gastroenterol. 1993 16 340-343... 

IgD 2 57 100 90% X type often have extraosseous lesion, amyloidosis, renal failure 50% have enlarged lymph nodes, hver, spleen poor prognosis... 

AL amyloidosis is the most common form of these disorders. Bone marrow plasmacytosis and excess plasma cell production of antigenicaHy identical monoclonal light chains are common to primary amyloidosis and multiple myeloma. Thus a clear distinction between these two conditions is not possible chemically. They appear to differ only in the presence or absence of osteolytic lesions. AL deposits may occur in the tongue, heart, lymph nodes, spleen, joints, peripheral nerves, and skin. 

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