Amyloidogenic region

F, Prediction of Amyloidogenic Regions and Structures of Amyloid Fibrils... 

In view of the consideration that /(-solenoids and /(-arcades may also be structural elements of amyloid fibrils (Kajava et al., 2004 Lazo and Downing, 1998 Margittai and Langen, 2004 Pickersgill, 2003), sequence-based detection and structure prediction of /(-solenoid proteins are pertinent to the identification of amyloidogenic sequences and the elucidation of amyloid fibril structures. As with /(-solenoid domains, amyloidogenic regions of... 

Nilsson MR, Raleigh DP. Analysis of amylin cleavage products provides new insights into the amyloidogenic region of human amylin. J. Molec. Biol. 1999 294 1375. 

Jones CE, Abdelraheim SR, Brown DR et al (2004) Preferential Cu2+ coordination by His96 and Hislll induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein. J Biol Chem 279 32018-32027... 

Members of tbe amyloid family bave no sequence homology with each other, but fibers formed from proteins in tiiis group share a similar secondary structure. Two characteristic reflections (at 10 and 4.8 A) are produced when fibers formed from any of the amyloid proteins are analyzed by x-ray diffraction (Sunde et al, 1997). This pattern defines the cross P-pleated sheet structure in which P sheets lie parallel to the long axis of the fiber, with tbe strands of each sheet oriented perpendicular to the fiber axis (Sunde et al, 1997). Fibers formed from tbe NM region of Sup35 share tbis structure (Serio etal, 2000) thus, Sup35 can be defined as an amyloidogenic protein. 

Wally J, Kica G, Zhang Y, et al. Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappal light chain. Biochim Biophys Acta 1999 1454(l) 49-56. 

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