Amyloid- 3-specific antibodies

Sumbria RK, Hui EK, Lu JZ (2013) Disaggregation of amyloid plaque in brain of Alzheimer s disease transgenic mice with daily subcutaneous administration of a tetravalent bi-specific antibody that targets the transferrin receptor and the Abeta amyloid peptide. Mol Pharm. doi 10.1021/mp400348n... 

Tsuzuki K, Fukatsu R, Takamaru Y et al. (1995) Amyloid beta protein in rat soleus muscle in chloroquine-induced myopathy using end-specific antibodies for Abeta40 and Abeta42 immunohisto-chemical evidence for amyloid beta protein. Neurosci Lett 202, 77-80. 

Hock, C., Konietzko, U., Papassotiropoulos, A., et al. (2002) Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer s disease. Nat. Med., 8,1270-1275. 

Barelli, H Lebeau, A., Vizzavona, J., et al. (1997) Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer s disease and cerebral amyloid angiopathy cases. Mol. Med. 3, 695-707. 

ApoSAA, normally a trace component of plasma, is an acute-phase plasma protein, that is, one that is elevated in a variety of disease states (R18). Its identification is interesting. A small protein of 76 residues, now called protein AA, was identified during the study of the proteins present in extracellular amyloid deposits in the type of amyloidosis particularly associated with inflammation (B24, H36, Lll, S38), Antibodies to protein AA reacted with two AA-related proteins in plasma, one of approximate Mr 180,000 (SAA) and the other found in HDL of Mr 14,000-15,000 or 12,000 (apoSAA) (A19, B25, B26, L12, L15). The N-terminal 76-amino-acid portion of apoSAA is identical to that of amyloid protein AA (E8). Human apoSAA has now been sequenced and has been shown to consist of 104 amino acid residues (B27). Further studies in man have demonstrated microheterogeneity in apoSAA (B18, B19, M30) and Benditt et al. describe specific amino acid substitutions (B27, P6). Shore et al. have described a second similar threonine-poor apolipoprotein, apparently a dimer of Mr 40,000... 

Bard F, Barbour R, Cannon C, Carretto R, Fox M, Games D, Guido T, Hoenow K, Hu K, Johnson-Wood K, Khan K, Kholodenko D, Lee C, Lee M, Motter R, Nguyen M, Reed A, Schenk D, Tang P, Vasquez N, Seubert P, Yednock T (2003) Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer s disease-like neuropathology. Proc Natl Acad Sci USA 100 2023-2028. 

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