Ampicillin thrombocytopenia with

Reports of drug-induced thrombocytopenia have been systematically reviewed (1). Among the 98 different drugs described in 561 articles the following antibiotics were found with level I (definite) evidence co-trimoxa-zole, rifampicin, vancomycin, sulfisoxazole, cefalothin, piperacillin, methicillin, novobiocin. Drugs with level II (probable) evidence were oxytetracycline and ampicillin. 

Brocks AP. Thrombocytopenia during treatment with ampicillin. Lancet 1974 2 273. 

Brogard JM, Bergoend H, Basset A (1969) Tolerance du traitement par la cephaloridine. Etude Clinique et application du test de Shelley aux recherches de sensibilisation croisee entre penicilline et cephaloridine. Nouv Presse Med 77 1539 Brooks AP (1974) Thrombocytopenia during treatment with ampicillin. Lancet 2 723 Brown BC, Price EV, Moore MB (1964) Penicilloyl-polylysine as an intradermal test of penicillin sensitivity. JAMA 189 599... 

Shapiro S, Slone D, Siskind V, Lewis GP, Jick H (1970) Ampicillin rashes. Lancet 1 194 Shapiro S, Heinonen OP, Lawson DH (1972) Excess of ampicillin rashes associated with al-lopurinol or hyperuricemia. N Engl J Med 286 505 Sheiman L, Speilvogel AE, Horowitz HI (1968) Thrombocytopenia caused by cephalothin sodium. Occurrence in a penicillin-sensitive individual. JAMA 203 601 Shelley WB (1963) Indirect basophil degranulation test for allergy to penicillin and other drugs. JAMA 184 171... 

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