AMPA receptors distribution

Regional distribution studies indicate that the highest density of kainate receptor occurs in the stratum lucidum of the hippocampus (mossy fiber system) and in the inner and outer layers of the neocortex. The highest density of NMDA receptors is found in the hippocampus, stratum radiatum, and in the striatum, thalamus, and cerebral cortex. The distribution of AMPA receptors is similar to that of NMDA receptors, but in the cerebellum AMPA receptors predominate in the molecular layer... 

Structure and Distribution of AMPA Receptor Subunits in Brain... 

Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll RA, Bredt DS (2003) Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol 161 805-816. 

Figure 5.15 Distribution of the predicted endpoint and outlier rating values for the activity (a) and selectivity (b) of the AMPA receptor antagonists.

Figure 5.16 Distribution of the predicted values of selectivity and activity to the AMPA receptor for the filtered virtual screening dataset.

NMDARs are relatively stable components of the postsynaptic membrane. For example, the basal rate of endocytosis of surface AMPA receptors in cultured cortical neurons is nearly threefold that of NMDARs (20,117). Thus, it is not surprising that synaptic plasticity is linked more to changes in numbers and distribution of surface AMPA receptors than it is to NMDARs consequently, studies on glutamate receptor internalization have focused more on AMPA receptors than on NMDARs. 

The three classes of ionotropic glutamate receptors- NMDA, AMPA, and kainate- are distributed extensively throughout the MOB. NMDA receptors are found in every layer of MOB except the IPL (Watanabe et ak, 1993 Monyer et al., 1994 Petralia et al., 1994b). AMPA receptors are found in all layers except the ONL and subependymal layer (Molnar et al., 1993 Martin et al., 1993 Petralia and Wenthold, 1992 van den Pol, 1995). Kainate receptors are found in the MGL, EPL, and IPL (Monaghan and Cotman, 1982 Gall et al., 1990 Miller et al., 1990 Wisden and Seeburg, 1993). 

AMPA RECEPTOR SUBUNITS — SUMMARY OF mRNA DISTRIBUTION... 

Fig. 2. Distribution of AMPA receptor flip and flop splice variant mRNAs in the adult rat brain (X-ray film autoradiographs, sagittal sections), cb. cerebellum cpu, caudate putamen ctx, netKorlex dg. dentate granule cells ob, olfactory bulb (Sommer et al.. 1990 Wisden, Seeburg and Monyer, unpublished). Scale bar. 10 mm.

AMPA RECEPTOR SUBUNIT mRNA DISTRIBUTION IN THE CAUDATE PUTAMEN... 

Bernard V, Bolam JP (1998) Subcellular and subsynaptic distribution of the NRl subunit of the NMDA receptor in the neostriatum and globus pallidus of the rat co-localization at synapses with the GluR2/3 subunit of the AMPA receptor. Eur J Neurosci 70 3721-3736. 

Engelman HS, Allen TB, MacDermott AB (1999) The distribution of neurons expressing Ca +-permeable AMPA receptors in the superficial laminae of the spinal cord dorsal horn. J Neurosci 79 2081-2089. 

Petralia RS, Wang YX, Mayat E, Wenthold RJ (1997) Glutamate receptor subunit 2-selective antibody shows a differential distribution of Ca-impermeable AMPA receptors among populations of neurons. J Comp Neurol 355 456-476. 

Kharazia VN, Weinberg RJ (1997) Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex. Neurosci Lett 258 41-44. 

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