AMPA receptors calcium permeability

Vandenberghe W, Robberecht W, Brorson JR (2000) AMPA receptor calcium permeability, GluR2 expression, and selective motorneuron vulnerability. J Neurosci 20 123-132. 

Some AMPA and kainate receptors are calcium permeable. Some of the antagonist structures are shown in Fig. 10.4. 

The AMPA receptors mediate the majority of fast excitatory neurotransmission in the mammalian brain. The rapid kinetics and the low Ca permeability make these receptors ideal for fast neurotransmission without sufficient changes in the intracellular calcium concentration to activate Ca2+-dependent processes. The NMDA receptors are co-localized with the AMPA receptors on many synapses, but the slow kinetics of the NMDA receptor minimize the receptor activation after a single presynaptic glutamate release where the neuron quickly repolarizes, resulting in Mg2+ block... 

Burnashev N, Khodorova A, Jonas P, Helm PJ, Wisden W, Monyer H, Seeburg PH, Sakmann B (1992) Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science 256 1566-1570. 

Liu SQ, Cull-Candy SG (2000) Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype. Nature 405 454-458. 

Engelman HS, Allen TB, MacDermott AB (1999) The distribution of neurons expressing calcium-permeable AMPA receptors in the superficial laminae of the spinal cord dorsal horn. J Neurosci 79 2081-2089. 

Spaethling, J.M., Klein, D.M., Singh, P., and Meaney, D.F., 2008. Calcium-permeable AMPA receptors appear in cortical neurons after traumatic mechanical injury and contribute to neuronal fate. Journal of Neuro trauma. 25 1207-1216. 

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