AMP analogs

Figure 6. AMP analogs containing modifications in the imidazole ring used in FEP calculations.

The addition of phosphodiesterase inhibitors such as isobutylmethylxanthine (IBMX) and cyclic AMP analogs such as the 8-bromo- and dibutyryl-derivatives resulted in a stimulation of synthesis which could not be blocked by the co-addition of opiates. This implies that opiates are exerting their effect at the level of adenylate cyclase activation. The actual effect of these drugs on cellular cyclic AMP levels was determined by radioimmunoassay as shown in Table III. 

AMP analogs and are potent prodrugs with selective activity against herpes simplex viruses (HSV) and retroviruses, ineluding human immunodeficiency viruses (HIV-1 and HIV-2)."... 

In less well controlled studies topical theophylline, with or without topical dibutyryl cyclic AMP or a cyclic AMP analog, has shown modest efficacy in psoriasis.29,30 An uncontrolled clinical trial of oral theophylline is said to have demonstrated beneficial results in psoriasis.31 In two uncontrolled clinical studies of intramuscular dibutyryl cyclic AMP, studies inspired by our earlier biochemical studies on cyclic nucleotides in psoriasis,Chinese physicians in Shanghai considered the drug effective in 80% of 69 patients treated.32,33 in the Chinese studies, reported side effects were insignificant and thus it should be possible to duplicate their study but using a double blind design. In view of the excellent re-... 

Biological Actions of Cyclic AMP Analogs George I. Drummond, David L, Severson e, 215... 

Schlag BD, Vondrasek JR, Munir M, Kalandadze A, Zelenaia OA, Rothstein JD, Robinson MB (1998) Regulation of the glial Na" "-dependent glutamate transporters by cyclic AMP analogs and neurons. Mol Pharmacol 53 355-369. 

In the physiological context, the malonyl-CoA level is controlled by the activity of ACC, which is phosphorylated/inactivated by AMPK. Changes in hypothalamic AMPK activity are consistent with the predicted changes in the malonyl-CoA level and food intake. Furthermore, central administration of the AMP analog, AICAR (5 -aminoimidazole-... 

The actions of LH and hCG are mediated by the LH receptor, while those of FSH are mediated by the FSH receptor. These receptors couple to G, to activate the adenylyl cyclase-cyclic AMP pathway and most, if not aU, of the actions of the gonadotropins can be mimicked by cyclic AMP analogs. 

Lopez-Toledano, M.A., Redondo, C., Lobo, M.V.T., Reimers, D., Herranz, A.S., Paino, C.L., et al. Tyrosine hydroxylase induction by basic fibroblast growth factor and cyclic AMP analogs in striatal neural stem cells role of ERK1/ERK2 mitogen-activated protein kinase and protein kinase C. J. Histochem. Cytochem. 52, 1177-1189 (2004) Louvet-Vallee, S. ERM proteins from cellular architecture to cell signaling. Biol. CeU 92, 305-316(2000)... 

Table 5. Ebzymatlc activity of adenosine carboxylic acids as AMP analogs (pH 6.4, 25°C).

Data Sheet, AD811—High performance video op amp, Analog Devices, Inc., Massachusetts. 

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