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Amoxycillin bioavailability

Amoxicillin (t) 1 h previously known as amoxycillin) is a structural analogue of ampicillin (below) and is better absorbed from the gut (especially after food), and for the same dose achieves approximately double the plasma concentration. Diarrhoea is less frequent with amoxicillin than with ampicillin. The oral dose is 250 mg 8-hourly a parenteral form is available but offers no advantage over ampicillin. For oral use, however, amoxicillin is preferred because of its greater bioavailability and fewer adverse effects. [Pg.219]

The intramuscular bioavailability of amoxycillin in pigs is 83%, based on intravenous injection of amoxycillin sodium and intramuscular injection of amoxycillin trihydrate 15% in oil (described as the conventional formulation) in the neck, 10 cm behind the ear, of pigs. The conventional formulation provides slow absorption of amoxycillin (MAT, 7.3 h), Cmax of 5.1 pg/mL and delays elimination of the drug (MRT .m. is 8.8 h compared with MRT .V. of 1.5 h). Administration of the long-acting formulation of amoxycillin trihydrate 15% in... [Pg.78]

Fig. 2.8 Effect of species and weight on the bioavailability of amoxycillin after intramuscular injection of amoxycillin trihydrate aqueous suspension (100mg/mL) at the same dose (7 mg/ kg) in the various species except cats (10-12mg/kg). Fig. 2.8 Effect of species and weight on the bioavailability of amoxycillin after intramuscular injection of amoxycillin trihydrate aqueous suspension (100mg/mL) at the same dose (7 mg/ kg) in the various species except cats (10-12mg/kg).
Agerso, H. Friis, C. (1998) Bioavailability of amoxycillin in pigs. Journal of Veterinary Pharmacology and Therapeutics, 21, 41-46. [Pg.86]

Baggot, J.D., Love, D.N., Stewart, J. Raus, J. (1988) Bioavailability and disposition kinetics of amoxycillin in neonatal foals. Equine Veterinary Journal, 20, 125-127. [Pg.264]

Staniforth DH, Lillystone RJ, Jackson D. Effect of food on die bioavailability and tolerance of clavulanic acid/amoxycillin combination. J Antimicrob Chemotiier (19 2) 10,131-9. [Pg.324]

Paulsen O, Hogland P, Walder M. No effect of omeprazole-induced hypoacidity on the bioavailability of amoxycillin andbacampicillin. ScandJInfectDis (1989)21,219-23. [Pg.973]

Cardaci G, Lambert JR, Aranda-Michel J, Underwood B. Omeprazole has no effect on die gastric mucosal bioavailability of amoxycillin. Gut (1995) 37 (Suppl 1), A90. [Pg.973]

Sjovall et al., (1978) compared the pharmacokinetics of bacampicillin, pivampicillin, ampicillin, and amoxycillin in humans. They showed that the differences in the area under the curve of the serum concentration time plots were small except for ampicillin, which was lower. Ehmebo et al., (1979) reported that the bioavailability of pivampicillin (92 18%) and bacampicillin (86 11%) was higher than that of ampicillin (62 17%). Zarowny et al., (1974) reported the absolute bioavailability of amoxycillin to be similar (89%) to that of the esters. [Pg.401]


See other pages where Amoxycillin bioavailability is mentioned: [Pg.3975]    [Pg.685]    [Pg.64]    [Pg.67]    [Pg.80]    [Pg.90]    [Pg.237]   
See also in sourсe #XX -- [ Pg.64 , Pg.65 , Pg.67 , Pg.80 ]




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Amoxycillin

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