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Ammonium acetate tablets

FIGURE 1.25 HPLC determination of impurities in a levothyroxin (L-T4) formulation. Experimental conditions Column, Chiralpak QN-AX (150 rum x 4 rum ID) mobile phase, acetonitrile-50 mM ammonium acetate (60 40, v/v) (pHa 4.5) flow rate, 0.7 mLmiu UV detection, 240 nm temperature, 25 C. Sample, T4-200 tablets (Uni-Pharma, Greece) containing 0.2 mg L-T4 sodium per tablet the tablet was pulverized, suspended in methanol-10 mM sodium hydroxide (1 1 v/v) and after ultrasonication for 5 min the residues were removed by filtration. An aliquot of 10 xL of the filtrate was directly injected. (Reproduced from H. Gika et al., J. Chromatogr. B, 800 193 (2004). With permission.)... [Pg.67]

AT, FB, and their impurities Tablets Acquity UPLC BEH C18 column (1.7 urci, 2.1 mm x 100 mm) Gradient elution of acetonitrile ammonium acetate (pH 4.7 0.01 M) Minimum detection limit -was atng/1 levels [15]... [Pg.64]

Sivasubramanian and Anilkumar [81] described a simple reversed-phase HPLC method for the determination of omeprazole and domperi-done from tablet formulations. The analysis was carried out on a Hypersil ODS Ci8 (15 cm x 4.6 mm, 5 /jm) column using a mobile phase of methanol- 0.1 M ammonium acetate, pH 4.9 (60 40). The flow-rate and rim time were 1 ml/min and 10 min, respectively. The eluent was monitored at 280 nm. The method was reproducible, with good resolution between omeprazole and domperidone. The detector response was linear in the concentration range of 10-60 /[Pg.222]

Sample preparation Weigh out an amount of finely powdered tablets or capstiles equivalent to about 25 mg of drug. Add 50 mL buffer, shake for 30 min, add 10 mL MeOH, make up to 100 mL with buffer, filter (0.45 p,m), inject a 20 pL aliquot. If the sample clumps when the buffer is added, agitate with a stirring rod and sonicate. (Buffer was MeOH 200 mM pH 4.7 ammonium acetate buffer water 55 10 35.)... [Pg.974]

CHAN-SCSNj, mw 192.32, N 29.13 wh crystalline tablets (from w), mp 95-8° (with color change to dk grn and then dec) very sol in w, sol in MeOH or acet si sol in eth and insol in CC14, CS, chlf. It can be prepd by three methods a)neutraIization of azido-dithiocarbonic acid with aq tetramethylam-monium hydroxide b)double decompn of Ba azidodithiocarbonate and tetramethylammonium sulfate and c)digestion of aq tetramethyl-ammonium izid with 9 si 3fc ss of CS as reqd by the equation... [Pg.637]


See other pages where Ammonium acetate tablets is mentioned: [Pg.524]    [Pg.274]    [Pg.318]    [Pg.318]    [Pg.718]    [Pg.337]    [Pg.515]    [Pg.96]   
See also in sourсe #XX -- [ Pg.305 ]




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Ammonium acetate

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