Warfarin Amlodipine

A 71-year-old man with type 2 diabetes taking amlodipine, warfarin, valsartan, hydrochlorothiazide, atenolol, and rosiglitazone was given fenofibrate. The HDL cholesterol fell from 0.96 to 0.60 mmol/1 but rose to 0.80 mmol/1 on changing the rosiglitazone to pioglitazone. 

Clinically important, potentially hazardous interactions with amlodipine, anisindione, anticoagulants, aprepitant, atorvastatin, barbiturates, benzodiazepines, butabarbital, carbamazepine, chlordiazepoxide, clarithromycin, clonazepam, dorazepate, corticosteroids, cyclosporine, dexamethasone, diazepam, dicumarol, erythromycin, ethotoin, felodipine, flurazepam, fluvastatin, fosphenytoin, isradipine, itraconazole, ketoconazole, lorazepam, lovastatin, mephenytoin, mephobarbital, midazolam, nicardipine, nifedipine, nimodipine, nisoldipine, oxazepam, pentobarbital, phenobarbital, pimozide, pravastatin, primidone, quazepam, rifampin, secobarbital, simvastatin, St John s wort, temazepam, warfarin... 

In pharmacological studies neither amlodipine nor felodipine affected the anticoagulant effects of warfarin. Similarly, although diltiazem may cause a minor decrease in warfarin metabolism, this did not alter the anticoagulant effect in two studies. 

The manufacturers say that amlodipine did not significantly alter the effect of warfarin on prothrombin times in healthy subjects. ... 

Calleri, E. De Lorenzi, E. Siluk, D. Markuszewski, M. Kaliszan, R. Massolini, G. Column liquid chromatography riboflavin binding protein-chiral stationary phase Investigation of retention mechanism, Chromatographia, 2002, 55, 651-658. [fenfluramine dichloroisoproterenol propranolol oxprenolol alprenolol acebutolol ketoprofen indoprofen warfarin lorazepam oxazepam isradipine nimodipine amlodipine nicardipine lercanidipine gallopamil verapamil bepridil]... 

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