Furazolidone Amitriptyline

Clinically important, potentially hazardous interactions with albuterol, alpha-blockers, amitriptyline, amoxapine, atenolol, beta-blockers, carteolol, chlorpromazine, clomipramine, cocaine, desipramine, doxepin, ephedra, ergotamine, furazolidone, halothane, imipramine, insulin detemir, MAO inhibitors, metoprolol, nadolol, nortriptyline, oxprenolol, penbutolol, phenelzine, phenoxybenzamine, phenylephrine, pindolol, prazosin, propranolol, protriptyline, sympathomimetics, terbutaline, thioridazine, timolol, tranylcypromine, tricyclic antidepressants, trimipramine, vasopressors... 

Aderhold RM and Muniz CE. Acute psychosis with amitriptyline and furazolidone. JAMA (1970)213,2080. 

A report describes the development of toxic psychosis, hyperactivity, sweating and hot and cold flushes in a woman taking amitriptyline with furazolidone, and diphenoxylate with atropine. 

A depressed woman taking daily doses of conjugated oestrogens 1.25 mg and amitriptyline 75 mg, was also given furazolidone 300 mg daily and diphenoxylate with atropine sulfate. Two days later she began to experi-enee blurred vision, profuse perspiration followed by alternate chills and hot flushes, restlessness, motor activity, persecutory delusions, auditory hallueinations and visual illusions. The symptoms cleared within a day of stopping the furazolidone. The reasons are not understood but the authors point out that furazolidone has MAO-inhibitory properties and that the symptoms were similar to those seen when the tricyclic antidepressants and MAOIs interaet. However the MAO-inhibitory activity of furazolidone normally develops over several days. Whether the concurrent use of atropine and amitriptyline (both of which have antimuscarinic activity)... 

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See also in sourсe #XX -- [ ]

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