Mizolastine Amiodarone

VENLAFAXINE 1. ANTIARRHYTHMICS - amiodarone, disopyramide, procainamide, propafenone 2. ANTIBIOTICS — macrolides (especially azithromycin, clarithromycin, parenteral erythromycin, telithromycin), quinolones (especially moxifloxacin), quinupristin/ dalfopristin 3. ANTICANCER AND IMMUNOMODULATING DRUGS -arsenic trioxide 4. ANTIDEPRESSANTS-TCAs 5. ANTIEMETICS-dolasetron 6. ANTIFUNGALS-fluconazole, posaconazole, voriconazole 7. ANTIHISTAMINES-terfenadine, hydroxyzine, mizolastine 8. ANTIMALARIALS -artemetherwith lumefantrine, chloro-quine, hydroxychloroquine, mefloquine, quinine 9. ANTIPROTOZOALS -pentamidine isetionate 10. ANTIPSY-CHOTICS - atypicals, phenothiazines, pimozide 11. BETA-BLOCKERS -sotalol 12. BRONCHODILATORS-parenteral bronchodilators 13. CNS STIMULANTS - atomoxetine Risk of ventricular arrhythmias, particularly torsades de pointes Additive effect these drugs cause prolongation of the Q-T interval Avoid co-administration... 

I. ANTIARRHYTHMICS - amiodarone, disopyramide, procainamide, propafenone 2. ANTIBIOTICS -macrolides (especially azithromycin, clarithromycin, parenteral erythromycin, telithromycin), quinolones (especially moxifloxacin), quinupristin/ dalfopristin 3. ANTICANCER AND IMMUNOMODULATING DRUGS-arsenic trioxide 4. ANTIDEPRESSANTS-TCAs, venlafaxine 5. ANTIEMETICS -dolasetron 6. ANTIHISTAMINES-terfenadine, hydroxyzine, mizolastine... 

A case of torsade de pointes occurred in an elderly woman taking amiodarone when she was also given loratadine, an antihistamine generally viewed as unlikely to have clinically relevant effects on the QT-interval. Combined effects on the QT interval would be expected if amiodarone was given with terfenadine or astemizole, and possibly also mizolastine. 

The general clinical relevance of this one case is uncertain, but the authors consider that the QT interval should be monitored if loratadine is given with other drugs that may potentially prolong the QT interval. Note that it is recommended that antihistamines with known potential for QT prolongation such as terfenadine and astemizole (see Table 15.2 , (p.583)) should not be used with amiodarone, and although there appear to be no cases of clinically relevant QT-prolongation with mizolastine, the manufacturers contraindicate concurrent amiodarone. ... 

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