3- Aminopyridine adenine dinucleotide

Chan, J.K., and Anderson, B.M. (1975) A novel diazonium-sulfhydryl reaction in the inactivation of yeast alcohol dehydrogenase by diazotized 3-aminopyridine adenine dinucleotide. J. Biol. Chem. 250, 67-72. 

Aminopyridine adenine dinucleotide. Purified by ion exchange chromatography [Fisher et al. JBC 248 4293 1973]. 

Aminopyridine adenine dinucleotide [21106-96-7] M 635.4 (see NAD for pK) Purified by ion exchange chromatography [Fisher et al. J Biol Chem 248 4293 1973 Anderson and Fisher Methods Enzymol 66 81 1980]. 

Periodate-oxidized NADP has been used as an affinity label for other NADP-specific enzymes including pigeon liver malic enzyme (72, 73), spinach ferre-doxin-NADP reductase (74, 75), and Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase (76). Recently, a new fluorescent dialdehyde derivative has been reported as an affinity label of NADP sites, namely, periodate-oxidized 3-aminopyridine adenine dinucleotide phosphate (77). 

Nicotinamide l,iV -ethenoadenine dinucleotide, prepared from NAD+ and chloroacetaldehyde, has been converted into 3-aminopyridine l,A -etheno-adenine dinucleotide (4) by a pyridine base exchange reaction which was catalysed by the venom of Bungarus fasciatus. Yeast alcohol dehydrogenase was... 

---