Aminoglycosides single daily dose

Aminoglycosides are often used in patients with gram-negative bacillary pneumonia. Single daily dosing may be of particular importance in patients with pneumonia, since this regimen can increase the peak concentration of the aminoglycosides in bronchial secretions. 

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Gilbert DN. Meta-analyses are no longer required for determining the efficacy of single daily dosing of aminoglycosides. Clin Infect Dis 1997 24 816-819. 

Marra F, Partoni N, Jewesson P, Aminoglycoside administrations as a single daily dose An improvement to current practice or a repeat of previous errors Drugs 1996 52 344-376. 

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Nordstrom L, Ringberg H, Cronberg S, Tjernstrom O, Walder M. Does administration of an aminoglycoside in a single daily dose affect its efficacy and toxicity J Antimicrob Chemother 1990 25 159-173. 

Galloe AM, Graudal N, Christensen EIR, Kampmann JP, Aminoglycosides single or multiple daily dosing, Eur J Pharmacol, 1995 48 39-43. 

Barza M, loannidis JP, Cappelleri JC, Lau J. Single or multiple daily doses of aminoglycosides a meta-analysis. BMJ 1996 312 338-345. 

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